Table 4 Cycle outcomes among women with no cancer, breast cancer +/− BRCA mutations, or other cancer
From: Responses to fertility treatment among patients with cancer: a retrospective cohort study
| Cycle characteristics | No Cancer (n = 664) | BRCA- Breast Cancer (n = 49) | BRCA+ Breast Cancer (n = 13) | Other Cancer (n = 68) |
|---|---|---|---|---|
| Woman’s Age at Stimulation (years) | 34.6 ± 4.2 | 34.7 ± 3.7 | 32.3 ± 4.0 | 28.5 ± 6.4 |
| Baseline AFC (n)1 | 9.4 ± 7.2 | 11.5 ± 7.7 | 7.7 ± 6.3 | 8.3 ± 7.8 |
| 1.00 (Ref) | 1.22 (0.99,1.50) | 0.76 (0.50,1.15) | 0.70 (0.54,0.90)* | |
| Starting FSH dose (IU)2 | 289.0 ± 121.3 | 342.0 ± 159.6 | 395.2 ± 236.5 | 375.5 ± 174.5 |
| 0.0 (Ref) | 53.5 (21.1,85.9)* | 142.8 (81.5204.1)* | 183.2 (153.3213.1)* | |
| Total FSH dose (IU)2 | 1839.2 ± 1294.7 | 2498.0 ± 1570.9 | 4326.9 ± 3046.6 | 2994.5 ± 1715.8 |
| 0.00 (Ref) | 637.7 (302.4,1044.9)* | 2775.0 (2072.0,3478.0)* | 1916.5 (1573.7,2259.4)* | |
| Duration of stimulation (days)1 | 11.7 ± 2.0 | 11.3 ± 2.4 | 13.0 ± 3.0 | 12.1 ± 2.0 |
| 1.00 (Ref) | 0.96 (0.91,1.02) | 1.12 (0.98,1.28) | 1.05 (1.00,1.10)* | |
| Total follicle number at hCG trigger (n)1 | 12.9 ± 6.6 | 12.1 ± 5.8 | 12.1 ± 5.5 | 13.3 ± 5.9 |
| 1.00 (Ref) | 0.95 (0.83,1.09) | 0.87 (0.68,1.12) | 0.85 (0.75,0.97)* | |
| Number of oocytes retrieved (n)1 | 15.7 ± 8.6 | 14.9 ± 9.6 | 15.5 ± 7.1 | 20.8 ± 19.7 |
| 1.00 (Ref) | 0.94 (0.78,1.12) | 0.86 (0.67,1.12) | 1.11 (0.84,1.45) | |
| Number of mature oocytes retrieved (n)1 | 12.0 ± 7.1 | 10.2 ± 5.9 | 11.5 ± 5.6 | 15.7 ± 12.4 |
| 1.00 (Ref) | 0.85 (0.72,0.99)* | 0.90 (0.69,1.16) | 1.08 (0.85,1.38) | |
| Proportion of mature oocytes (n/n)1 | 0.76 ± 0.19 | 0.78 ± 0.21 | 0.79 ± 0.07 | 0.80 ± 0.16 |
| 1.00 (Ref) | 0.97 (0.78,1.19) | 1.23 (0.94,1.60) | 0.94 (0.69,1.26) | |
| Oocytes/AFC ratio (n/n)1 | 2.28 ± 2.87 | 1.85 ± 2.15 | 2.29 ± 1.25 | 3.19 ± 5.71 |
| 1.00 (Ref) | 0.73 (0.46,1.18) | 1.37 (0.66,2.82) | 1.69 (0.95,2.98) | |
| Mature oocytes/AFC ratio (n/n)1 | 1.76 ± 2.33 | 1.29 ± 1.43 | 1.77 ± 0.94 | 2.39 ± 3.93 |
| 1.00 (Ref) | 0.66 (0.41,1.06) | 1.37 (0.66,2.80) | 1.62 (0.94,2.80) | |
| Number of embryos (n)3 | 8.9 ± 6.3 | 8.0 ± 10.0 | 6.4 ± 5.7 | 6.2 ± 6.7 |
| 1.00 (Ref) | 0.84 (0.74,0.97)* | 0.90 (0.67,1.21) | 1.09 (0.98,1.23) | |
| Cycle cancelled [n (%)]4 | 14 (2.1) | 0 (0) | 2 (15.4) | 8 (11.8) |
| 1.00 (Ref) | – | 8.55 (1.70,42.88)* | 6.06 (2.12,17.35)* |