Table 3 Ovarian stimulation cycle outcomes among women without cancer and women with local or systemic cancer
From: Responses to fertility treatment among patients with cancer: a retrospective cohort study
| Cycle characteristic | No Cancer (n = 664) | Local Cancer (n = 105) | Systemic Cancer (n = 42) |
|---|---|---|---|
| Woman’s Age at Stimulation (years) | 34.6 ± 4.2 | 33.6 ± 4.8 | 27.1 ± 6.4 |
| Baseline AFC (n)1 | 9.4 ± 7.2 | 10.1 ± 7.4 | 7.3 ± 7.5 |
| 1.00 (Ref) | 1.03 (0.89,1.21) | 0.58 (0.41,0.83)* | |
| 1.00 (Ref) | 0.64 (0.42,0.97)* | ||
| Starting FSH dose (IU)2 | 289.0 ± 121.3 | 354.2 ± 170.6 | 417.8 ± 180.7 |
| 0.00 (Ref) | 80.9 (58.2103.6)* | 252.4 (215.8289.1)* | |
| 0.00 (Ref) | 158.80 (95.7221.9)* | ||
| Total FSH dose (IU)2 | 1839.2 ± 1294.7 | 2813.6 ± 1785.6 | 3358.9 ± 2147.3 |
| 0.00 (Ref) | 1094.0 (825.9,1362.1)* | 2483.0 (2050.8,2915.2)* | |
| 0.00 (Ref) | 1124.82 (380.5,1869.2)* | ||
| Duration of stimulation (days)1 | 11.7 ± 2.0 | 11.7 ± 2.3 | 12.2 ± 2.2 |
| 1.00 (Ref) | 1.00 (0.96,1.04) | 1.06 (0.99,1.14) | |
| 1.00 (Ref) | 1.03 (0.94,1.12) | ||
| Total follicle number at hCG trigger (n)1 | 12.9 ± 6.6 | 12.2 ± 8.4 | 13.2 ± 5.90 |
| 1.00 (Ref) | 0.94 (0.85,1.04) | 0.81 (0.68,0.96)* | |
| 1.00 (Ref) | 0.91 (0.75–1.12) | ||
| Number of oocytes retrieved (n)1 | 15.7 ± 8.6 | 16.8 ± 13.6 | 20.6 ± 21.0 |
| 1.00 (Ref) | 1.04 (0.89,1.21) | 1.03 (0.68,1.55) | |
| 1.00 (Ref) | 1.05 (0.60,1.86) | ||
| Number of mature oocytes retrieved (n)1 | 12.0 ± 7.1 | 12.2 ± 8.4 | 16.0 ± 14.8 |
| 1.00 (Ref) | 0.99 (0.86,1.13) | 1.02 (0.70,1.50) | |
| 1.00 (Ref) | 1.12 (0.68,1.84) | ||
| Proportion of mature oocytes (n/n)1 | 0.76 ± 0.19 | 0.76 ± 0.20 | 0.78 ± 0.15 |
| 1.00 (Ref) | 0.96 (0.81,1.14) | 0.93 (0.60,1.42) | |
| 1.00 (Ref) | 0.94 (0.57,1.52) | ||
| Oocytes/AFC ratio (n/n)1 | 2.28 ± 2.87 | 2.06 ± 2.11 | 3.92 ± 7.35 |
| 1.00 (Ref) | 0.93 (0.67,1.28) | 2.29 (1.01,5.23)* | |
| 1.00 (Ref) | 2.15 (0.86,5.40) | ||
| Mature oocytes/AFC ratio (n/n)1 | 1.76 ± 2.33 | 1.56 ± 1.59 | 2.82 ± 4.97 |
| 1.00 (Ref) | 0.90 (0.65,1.25) | 2.09 (0.94,4.65) | |
| 1.00 (Ref) | 2.01 (0.81,4.99) | ||
| Number of embryos (n)3 | 8.9 ± 6.3 | 8.8 ± 6.4 | 12.3 ± 11.7 |
| 1.00 (Ref) | 0.93 (0.85,1.03) | 1.03 (0.88,1.19) | |
| 1.00 (Ref) | 1.16 (0.98,1.39) | ||
| Cycle Cancelled [n (%)]4 | 14 ± 2.1 | 2 ± 1.9 | 9 ± 21.4 |
| 1.00 (Ref) | 0.92 (0.21,4.11) | 14.41 (4.83,42.98)* | |
| 1.00 (Ref) | 17.03 (2.94,98.71)* |