Discrete survival model analysis of a couple’s smoking pattern and outcomes of assisted reproduction

Table 4 Hazard ratios for failing ART by continuous smoking patterns (EARTH study, N = 225 couples, 354 ART cycles)

Smoking Pattern	Adjusted Hazard Ratio (95% CI)	P-Value
Female Smoking Intensity and Duration ^a
Per 1 additional cigarette per day	1.02 (0.97, 1.08)	0.45
Per 1 additional year of smoking	1.01 (0.97, 1.05)	0.68
Female Smoking Cessation ^b
Per 1 additional year of smoking cessation	1.01 (0.95, 1.08)	0.69
Female Age of Smoking Initiation ^c
Per 1 additional year later smoking initiation	0.90 (0.79, 1.02)	0.11
Male Smoking Intensity and Duration ^a
Per 1 additional cigarette per day	0.99 (0.97, 1.01)	0.36
Per 1 additional year of smoking	1.01 (0.99, 1.04)	0.25
Male Smoking Cessation ^b
Per 1 additional year of smoking cessation	0.96 (0.91, 1.00)	0.05
Male Age of Smoking Initiation ^c
Per 1 additional year later smoking initiation	1.04 (0.91, 1.19)	0.58

^aIncluded all couples and cycles (N = 354 cycles). Data is presented as the cumulative hazard ratio for failing ART at any point per 1 unit increase of smoking intensity (continuous, centered average cigarettes/day) and total years of smoking (continuous, centered years). The model was adjusted for female age and BMI, protocol, educational status, current smoking status and partner’s smoking status
^bLimited to ever smokers only (N = 105 cycles for women; N = 119 cycles for men). Data is presented as the cumulative hazard ratio for failing ART at any point per 1 unit increase of smoking cessation (centered, continuous years). The model was adjusted for female age and BMI, protocol, educational status, pack-years history and partner’s smoking status
^cLimited to ever smokers only (N = 105 cycles for women; N = 119 cycles for men). Data is presented as the cumulative hazard ratio for failing ART at any point per 1 unit increase of smoking age at initiation (centered, continuous years). The model was adjusted for female age and BMI, protocol, educational status, pack-years history, current smoking status and partner’s smoking status

ISSN: 2054-7099