Polycystic ovary syndrome and risk of endometrial, ovarian, and breast cancer: a systematic review

Table 2 Studies of PCOS and endometrial cancer risk

Author	Year	Study design	Endometrial Cancer Cases (n)	Overall result RR (95% CI)
Gottschau	2015	Registry cohort (Denmark)	16	3.9 (2.2–6.3)^a
Shen	2015	Registry cohort (Taiwan)	7	4.7 (1.6–14.1)^a
Barry^b	2014	Meta-analysis	1264	2.8 (1.3–6.0)^a
Haoula^c	2012	Meta-analysis	938	2.9 (1.5–5.5)^a
Brinton^d	2010	Cohort (US)	15	2.0 (1.1–3.3)^a
Fearnley^e	2010	Case control (Australia)	156	2.2 (0.9–5.7)
Chittenden^f	2009	Meta-analysis	667	2.7 (1.0–7.3)^c
Zucchetto	2009	Case–control (Italy)	454	1.3 (0.7–2.2)
Iatrakis^e	2006	Case–control (Greece)	81	9.0 (0.5–176.0)^a,g
Pillay^h	2006	Cross-sectional (UK)	128	1.0 (0.4–2.7)^a,c
Niwa	2000	Case–control (Japan)	136	8.9 (0.4–184.9)^a,g
Wild	2000	Cohort (UK)	11	6.1 (1.0–36.9)
Escobedo	1991	Case–control (US)	437	5.4 (2.4–12.3)^a
Coulamⁱ	1983	Cohort (US)	5	3.1 (1.1–7.3)^a

^a Effect estimate not adjusted for BMI
^b This meta-analysis includes the studies by Fearnley, Zucchetto, Iatrakis, Niwa, and Escobedo
^c This meta-analysis includes the studies by Fearnley, Iatrakis, Pillay, Niwa, and Escobedo
^d In this study, androgen excess or menstrual disorders was evaluated rather than PCOS
^e This study only included women less than 50 years old
^f This meta-analysis includes the studies by Iatrakis, Pillay, Niwa, and Escobedo
^g Odds ratio was calculated based on numbers provided in the paper
^h In this study, polycystic ovary morphology was evaluated rather than PCOS
ⁱ In this study, chronic anovulation syndrome was evaluated rather than PCOS

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